The efficacy of mycamine against infections caused by fungi other than candida has not been established. Aeruginosa isolates tested, micafungin significantly reduced biofilm biomass. Epinephrine, hydrocortisone, isoproterenol, lidocaine, micafungin, multiple vitamin infusion, potassium. Micafungin side effects, dosage, interactions drugs.
Stability and compatibility of antimicrobial lock solutions p. This study of micafungin pharmacokinetics included 36 patients 24 male and 12 female aged between 22 and 84 years. Micafungin trade name mycamine is an echinocandin antifungal drug used to treat and prevent invasive fungal infections including candidemia, abscesses and esophageal candidiasis. Mycamine has not been adequately studied in patients with endocarditis, osteomyelitis and meningoencephalitis due to candida.
Linear relationship between dose and auc over dosage range of 50150 mg daily and 38 mgkg daily. Renal dose adjustment guidelines for antimicrobials crrt. The following is the list of drugs found on the king guide to parenteral admixtures critical care admixtures wall chart. For treatment of esophageal candidiasis, add 150 mg of micafungin to 100 ml of 0. Thames valley ysite intravenous drugs compatibility chart march. Micafungin injection is used to help the body overcome serious fungus. Treatment of oesophageal candidiasis in patients for whom intravenous.
Reconstituted vials and infusion are stable for 24 hr at room temperature. Treatment of candidemia, acute disseminated candidiasis, candida peritonitis and abscesses in adult and. Based on the limited data, an echinocandin drug eg, anidulafungin, caspofungin, micafungin is recommended by the cdc as initial therapy for treatment of c auris infections in adults and children aged. Echinocandins are recommended as initial treatment for invasive fungal. Micafungin is an antifungal agent that inhibits the synthesis of glucan, an essential component of fungal cell walls.
The stability of micafungin sodium in polypropylene syringes and glass bottles was studied at different concentrations. We selected 55 injectable drugs analyzed individually with two types of parenteral nutrition. Patients who receive micafungin infusion may be receiving many other parenteral drugs via ysite coadministration, including anti infectives, antiemetics. Micafungin sodium is a semisynthetic lipopeptide 12 echinocandin synthesized by a chemical modification of a fermentation product of coleophoma empetri f11899. Micafungin is an antifungal agent known to inhibit 1,3. Compare prices and print coupons for mycamine micafungin and other candidiasis and thrush drugs at cvs, walgreens, and other pharmacies. Intravenous compatibility chart drug information for. Dglucan, 14 an integral component of the fungal cell wall. Stability of micafungin sodium solutions at different. With its expanded coverage, many updates, and new information, extended stability provides even more support, making it a must have for any practice in which pharmaceutical solutions are prepared and administered. Compatibility depends upon many factors including temperature, ph, iv fluid, concentration, order of mixing and brand of drug.
Physical compatibility of micafungin with sodium bicarbonate. Data are not available regarding the presence of micafungin in human milk, effects on breastfed infants, or effects on milk production. Micafungin sodium administration to pregnant rabbits intravenous dosing. Micafungin definition of micafungin by medical dictionary. Parenteral nutrition pn and drug compatibility the coinfusion of drugs and pn should be avoided.
Check tubing below ysite carefully for discoloration, cloudiness or. Stability and compatibility of antimicrobial lock solutions. Micafungin central line required for concentrations 1. How to use micafungin 100 mg intravenous solution antifungals glucan synthesis inhibitors echinocandins this medication is given by injection into a vein as directed by your doctor, usually. Side effects of mycamine micafungin sodium, warnings, uses. Micafungin intravenous route description and brand names. Drug manufacturer lot number concentrationa albumin, human zlb biopharma 0431900087 25%b aminophylline american regent 4021 2. Do not mix micafungin with any other medicines, or give other medicines.
Recent epidemiologic literature indicates that candidal species resistant to azoles are becoming more prevalent in the face of increasing incidence of hospitalizations with candidemia. Intravenous administration of formulary medications uw health. Current fda thinking on stability practices for new drug. The iv drug compatibility chart is based on information from the handbook of injectable drugs, 16th edition, by lawrence a. Mycamine should be administered once daily by intravenous infusion. In critically ill patients the incidence of invasive fungal infections caused by candida spp. Each singleuse vial contains 50 mg or 100 mg micafungin sodium, 200 mg. The preferred initial treatment is an echinocandin micafungin 100 mg intravenously iv daily. Mycamine is a sterile, lyophilized product for intravenous iv infusion that contains micafungin sodium.
Micafungin sodium pharmacokinetics absorption plasma concentrations. A clear and concise compatibility chart can be a useful tool in helping to deliver safe, highquality iv therapy to patients. Iv drug compatibility chart the iv drug compatibility chart is based on information from the handbook of injectable drugs, 16th edition, by lawrence a. You should also ensure that the drugs checked are compatible in terms. The overall safety of mycamine was assessed in 3227 adult and pediatric patients and 520 volunteers in 46 clinical trials, including the invasive candidiasis, esophageal. Micafungin sodium is a lightsensitive, hygroscopic white powder that is freely soluble in water, isotonic sodium chloride solution, n,ndimethylformamide and dimethylsulfoxide, slightly soluble in methyl alcohol, and practically insoluble in acetonitrile, ethyl alcohol 95%, acetone, diethyl ether and nhexane. Mycamine micafungin dosing, indications, interactions. The intravenous iv administration of a wide range of medications often utilizes acidic vehicles eg, 0. Compatibility of micafungin injection with other drugs.
Micafungin sodium is a semisynthetic lipopeptide 12 echinocandin synthesized by a. Micafungin versus anidulafungin in critically ill patients. Micafungin sodium is a semisynthetic lipopeptide echinocandin synthesized by a chemical. Pharmacokinetics of micafungin in critically ill patients. Unchanged micafungin is the principal circulating compound in systemic circulation. Micafungin was present in the milk of lactating rats following iv. Mycamine vials by aseptically adding 5 ml of one of the following compatible solutions. Mycamine 50mg and 100mg powder for concentrate for.
Micafungin must be given slowly through an iv infusion, and each injection can take at least 1 hour to complete. Mycamine micafungin sodium for intravenous infusion. Mycamine is a sterile, lyophilized product for intravenous iv infusion that. The purpose of this study was to determine the physical compatibility of micafungin with commonly used concentrations of sodium bicarbonate hydration fluids administered via a ysite. Trissel, fashp, 2010, american society of healthsystem. The objective of this study was to evaluate the physical compatibility of micafungin injection with selected other drugs during simulated ysite coadministration. The dosage depends on the indication and the bodyweight of the. Drug manufacturer lot number concentrationa albumin, human zlb biopharma 0431900087 25%b. This iv drug compatibility chart is provided as a quick reference, however since information is subject to change it is advised that you check with a pharmacist for recommendations as well as product information to check for any changes or additional incompatibilities.
The new information for micafungin includes admixture compatibility data for micafungin in combination with 49 different parenteral products. Mycamine micafungin for injection, for intravenous use. Micafungin does not allow candida fungi to replicate. Pn solutions are diverse in their composition and compatibilities with drugs can never be. This table can be used for ysite compatibility at the usual manufacturers concentrations.
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